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The metabolite BH4 controls T cell proliferation in autoimmunity and cancer


Nature.com - Nov 7, 2018
Kynurenine—a tryptophan metabolite that blocks antitumour immunity—inhibits T cell proliferation in a manner that can be rescued by BH4. Finally, we report the development of a potent SPR antagonist for possible clinical use. Our data uncover GCH1 ...
 

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling


Nature.com - Oct 15, 2018
Inhibition of PGK1 results in accumulation of the reactive metabolite methylglyoxal, which selectively modifies KEAP1 to form a methylimidazole crosslink between proximal cysteine and arginine residues (MICA). This posttranslational modification ...
 

Immunity connects gut bacteria and aging


Medical Xpress - Nov 13, 2018
"Lactic acid, a metabolite produced by the bacterium Lactobacillus plantarum, is incorporated and processed in the fly intestine, with the side-effect of producing reactive oxygen species that promote epithelial damage." The researchers speculate that ...
 

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What is a Primary and Secondary Metabolite?


What is a Primary and Secondary Metabolite? Dr. Dan answers. Shop Core Health here: http://bit.ly/CoreHealthInfo Find us here: http://www.unicity.com/ ...
 

Primary and Secondary Metabolites


Class 11: Biology: Biomolecules: Primary and Secondary Metabolites.
 

Metabolite


Metabolites are the intermediates and products of metabolism. A term metabolite is usually restricted to small molecules. Metabolites have various functions, ...
 

Primary and secondary metabolites


Primary and secondary metabolites Watch more Videos at https://www.tutorialspoint.com/videotutorials/index.htm Lecture By: Ms.Deepti Trivedi, Tutorials Point ...
 

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